Elimination of senescent cells inhibits epithelial-mesenchymal transition of retinal pigment epithelial cells
| Autor: | Furong Gao, Lei Wang, Binxin Wu, Qingjian Ou, Haibin Tian, Jingying Xu, Caixia Jin, Jieping Zhang, Juan Wang, Lixia Lu, Guo-Tong Xu |
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| Rok vydání: | 2022 |
| Předmět: |
Epithelial-Mesenchymal Transition
Dasatinib Epithelial Cells Hydrogen Peroxide Retinal Pigment Epithelium Sensory Systems Cellular and Molecular Neuroscience Ophthalmology Macular Degeneration Transforming Growth Factor beta Culture Media Conditioned Humans Quercetin Retinal Pigments Cellular Senescence |
| Zdroj: | Experimental eye research. 223 |
| ISSN: | 1096-0007 |
| Popis: | Age-related macular degeneration (AMD) is one of the most common leading causes of irreversible blindness, and there is no effective treatment for it. It has been reported that aging is the greatest risk factor for AMD, and epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells plays an important role in the pathogenesis of AMD. To clarify the relationship between senescence and EMT in RPE cells, we used the replicative senescence model, H |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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