Hepatocyte-derived microRNAs as sensitive serum biomarkers of hepatocellular injury in Labrador retrievers
| Autor: | Dirksen, K, Verzijl, T, van den Ingh, T S G A M, Vernooij, J C M, van der Laan, L J W, Burgener, I A, Spee, B, Fieten, H, Spoedkliniek Gezelschapsdieren Midden-NL, LS Theoretische Epidemiologie, Leerstoel Orobio de Castro, LS Interne geneeskunde, Onderzoek, dCSCA RMSC-1, dCSCA AVR |
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| Přispěvatelé: | Spoedkliniek Gezelschapsdieren Midden-NL, LS Theoretische Epidemiologie, Leerstoel Orobio de Castro, LS Interne geneeskunde, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Surgery, Epidemiology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty 040301 veterinary sciences Hepatitis Animal Gastroenterology Hepatitis 0403 veterinary science 03 medical and health sciences Hepatocellular injury Dogs SDG 3 - Good Health and Well-being Internal medicine medicine Animals Dog Diseases Subclinical infection Liver injury General Veterinary biology business.industry Alanine Transaminase MicroRNA 04 agricultural and veterinary sciences Biomarker medicine.disease Confidence interval MicroRNAs 030104 developmental biology medicine.anatomical_structure Alanine transaminase Hepatocyte Hepatocytes biology.protein Alanine aminotransferase Biomarker (medicine) Female Animal Science and Zoology Histopathology Chemical and Drug Induced Liver Injury business Biomarkers Copper |
| Zdroj: | Veterinary Journal, 211, 75. Bailliere Tindall Ltd Veterinary Journal, 211, 75-81. Bailliere Tindall Ltd |
| ISSN: | 1090-0233 |
| Popis: | Common parenchymal liver diseases in dogs include reactive hepatopathies and primary hepatitis (acute or chronic). In chronic hepatitis, there is usually a long subclinical phase. Specific clinical signs become overt only when liver damage is severe and in this phase, treatment is usually less effective. Limited data are available regarding the sensitivity of liver enzyme activity or biomarkers for early detection of sub clinical hepatitis. Hepatocyte-derived microRNAs (HDmiRs) were recently identified as promising biomarkers for hepatocellular injury in multiple species. Here, the potential of the HDmiRs miR-122 and miR-148a as sensitive diagnostic biomarkers for hepatocellular injury in Labrador retrievers was investigated. Samples from 66 Labrador retrievers with histologically normal livers, high hepatic copper, and with various forms of liver injury were evaluated for serum alanine aminotransferase (ALT) activity and microRNA values. Median values of HDmiR-122 were 34.6 times higher in dogs with liver injury and high ALT than in normal dogs (95% confidence intervals [CI], 13-95; P |
| Databáze: | OpenAIRE |
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