| Autor: |
Mohammed Asker, Jean‐Philippe Krieger, Amber Liles, Ian C. Tinsley, Tito Borner, Ivana Maric, Sarah Doebley, C. Daniel Furst, Stina Börchers, Francesco Longo, Yashaswini R. Bhat, Bart C. De Jonghe, Matthew R. Hayes, Robert P. Doyle, Karolina P. Skibicka |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Diabetes, obesitymetabolism. |
| ISSN: |
1463-1326 |
| Popis: |
Oxytocin (OT) has a well-established role in reproductive behaviors, however, it recently emerged as an important regulator of energy homeostasis. In addition to CNS, OT is found in the plasma and oxytocin receptors (OT-R) are found in peripheral tissues relevant to energy balance regulation. Here we aim to determine whether peripheral OT-R activation is sufficient to alter energy intake and expenditure.We first show that systemic OT potently reduced food intake and food-motivated behavior for a high-fat reward in male and female rats. Since it is plausible that peripherally, intraperitoneally (IP) injected OT crosses the blood brain barrier (BBB) to produce some of the metabolic effects within the CNS, we screened, with a novel fluorescently labeled-OT (fAF546-OT, Roxy), for the presence of IP-injected Roxy in CNS tissue relevant to feeding control and compared such to BBB-impermeable fluorescent OT-BTogether our data indicate that limiting systemic OT CNS penetrance preserves the anorexic effects of the peptide and reduces the clinically undesired side-effects of OT: emesis, taste avoidance, and locomotor depression. Thus, therapeutic targeting of peripheral OT-R may be a viable strategy to achieve appetite suppression with better patient outcomes. This article is protected by copyright. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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