Complications after Radiofrequency Ablation for Hepatocellular Carcinoma: A Multicenter Study Involving 9,411 Japanese Patients
| Autor: | Atsushi Hiraoka, Kazuhisa Yabushita, Haruhiko Kobashi, Takakazu Nagahara, Chikara Ogawa, Masaki Maeda, Kazuhiro Nouso, Hiroshi Aikata, Isao Sakaida, Mari Mandai, Issei Saeki, Masahiko Koda, Tomomitsu Matono, Hiroshi Shibata, Yasuyuki Araki, Koichi Takaguchi, Akemi Tsutsui, Shuichi Sato, Shinichiro Nakamura, Tomohiko Mannami, Takahito Yagi, Joji Tani, Akeri Mitsuda, Takahiro Yamasaki, Hiroyuki Takabatake, Takashi Moriya, Mikiya Kitamoto, Kazuya Kariyama, Shintaro Takaki, Tetsu Tomonari, Kouji Joko |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Local Ablation Therapy Radiofrequency ablation law.invention 03 medical and health sciences 0302 clinical medicine law medicine Tumor location Minimally invasive procedures Original Paper Hepatology business.industry Mortality rate Complication Hepatocellular carcinoma Mortality medicine.disease Surgery surgical procedures operative Oncology Multicenter study 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business therapeutics |
| Zdroj: | LIVER CANCER. 9(1):50-62 |
| ISSN: | 2235-1795 |
| Popis: | Introduction: Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is considered a safe and minimally invasive procedure. We previously reported that the mortality and complication rates for RFA were 0.038% (5/13,283 patients) and 3.54% (579 complications/16,346 procedures), respectively, from 1999 to 2010 (previous period). In this study, we investigated the clinical criteria for RFA and the mortality and complication rates from 2011 to 2015 (recent period). Methods: Data were collected from 25 centers by using a questionnaire developed by the Chugoku-Shikoku Society for Local Ablation Therapy of HCC. The criteria for RFA, RFA modification, use of image-guidance modalities, mortality, and complications during the previous and recent periods were compared. Results: We evaluated 11,298 procedures for 9,411 patients, including those that involved new devices (bipolar RFA and internally adjustable electrode system). The criterion of hepatic function for RFA increased from a Child-Pugh score ≤8 during the previous period to ≤9 during the recent period. The criteria regarding the tumor location and other risk factors have been expanded recently because of the increased use of several modifications of the RFA procedure and image-guidance modalities. The mortality rate was 0.064% (6/9,411 patients), and the complication rate was 2.92% (330 complications/11,298 procedures). There was no difference in mortality rates between the 2 periods (p = 0.38), but the complication rates was significantly lower during the recent period (p = 0.038). Discussion and Conclusions: Our findings confirmed that RFA, including the use of new devices, is a low-risk procedure for HCC, despite the expansion of the criteria for RFA during the recent period. |
| Databáze: | OpenAIRE |
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