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Oxidative stress parameters in atherosclerotic cardiovascular disease high and low risk score groups as indicators for acute myocardial infarction Mathew John1, Priyanka S2, Joann B George3, Evelyn Maria4, Govindan Unni5 1-4 Jubilee Centre for Medical Research, Jubilee Mission Medical College & Research Institute, Thrissur, Kerala, INDIA 5 Department of Cardiology, Jubilee Mission Medical College & Research Institute, Thrissur,Kerala, INDIA mathewjohn@jmmc.ac.in, priyankanageswar@gmail.com, joanngeorge97@gmail.com, evu1joemercy@gmail.com, unni.govindan@gmail.com Abstract Background Coronary artery diseases (CAD) are the leading cause of morbidity and mortality worldwide. Oxidative stress is an important event associated with CAD and dictates the associated pathophysiology. The imbalance in pro oxidants and antioxidants occurs during myocardial infarction and can cause damage to myocardium. Hence, it is worth investigating the oxidative stress status in atherosclerotic high risk group which may lead to myocardial infarction. Further, the comparative investigation of oxidative stress parameters between NSTEMI and STEMI variants of myocardial infarction in ECG helps to identify the differential response of pro and antioxidants according to the extent of coronary artery occlusion. Objective To study the role of oxidative stress molecules as early indicators of myocardial infarction in atherosclerotic disease high risk factor group. To investigate the antioxidant enzymes had any differential activity between NSTEMI and STEMI variants of myocardial infarction which can be indicators for severity of coronary artery occlusion. Materials and methods The study is designed as a comparative analysis of oxidative stress parameters between atherosclerotic disease high risk score category and low risk score category and between NSTEMI and STEMI variants in ECG during myocardial infarction. The sample size was n=26 in each group. The oxidative stress parameters were assessed in blood plasma of participants according to established methods. The statistics was done in Microsoft excel and students t test was used for comparison between groups and p value less than 0.05 considered as significant. Results The study observed that the antioxidant parameters such as catalase and glutathione had lowered activity in ASCVD high risk group compared to low risk group and no significant change was observed in superoxide dismutase and thiobarbituric acid reacting substances. We also observed that both antioxidant enzymes, Catalase and SOD had significantly lowered activity in STEMI vs NSTEMI variants in ECG of myocardial infarction group. Conclusion The study concluded that antioxidant enzymes lowered during ASCVD high risk category could be used as early indicators for acute myocardial infarction. Key words: oxidative stress, antioxidants, catalase, superoxide dismutase URL:https://www.ijmst.org/papers-published/ijmst-2021-volume-10-issue-1 |
