GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response
| Autor: | Shiying Dang, Lin Chen, Xiao-Yong Zhan, Fei Yin, Ke Huang, Yun Li, Yang Kang, Yuhong Liang, Nan Wang, Tianshun Gao, Xing Xiao, Yi Zhang, Bihui Huang, Nannan Lai, Changfei Qin, Chuanming Luo, Yang Leng |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Myeloid business.industry medicine.medical_treatment DNA damage repair (DDR) Neoplasms. Tumors. Oncology. Including cancer and carcinogens gene classifier Immunotherapy medicine.disease lung adenocarcinoma immune check inhibitor (ICI) GDPLichi Haematopoiesis medicine.anatomical_structure Immune system Oncology Cancer research Medicine Adenocarcinoma Stem cell business Lung cancer RC254-282 CD8 Original Research |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| ISSN: | 2234-943X |
| Popis: | Lung cancer is one of the most common and mortal malignancies, usually with a poor prognosis in its advanced or recurrent stages. Recently, immune checkpoint inhibitors (ICIs) immunotherapy has revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD), and significantly improved patients’ prognoses. However, the prognostic and predictive outcomes differ because of tumor heterogeneity. Here, we present an effective method, GDPLichi (Genes of DNA damage repair to predict LUAD immune checkpoint inhibitors response), as the signature to predict the LUAD patient’s response to the ICIs. GDPLichi utilized only 7 maker genes from 8 DDR pathways to construct the predictive model and classified LUAD patients into two subgroups: low- and high-risk groups. The high-risk group was featured by worse prognosis and decreased B cells, CD8+ T cells, CD8+ central memory T cells, hematopoietic stem cells (HSC), myeloid dendritic cells (MDC), and immune scores as compared to the low-risk group. However, our research also suggests that the high-risk group was more sensitive to ICIs, which might be explained by increased TMB, neoantigen, immune checkpoint molecules, and immune suppression genes’ expression, but lower TIDE score as compared to the low-risk group. This conclusion was verified in three other LUAD cohort datasets (GSE30219, GSE31210, GSE50081). |
| Databáze: | OpenAIRE |
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