Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggresive breast cancer
| Autor: | Ariel P Otte, Jarle B. Arnes, Ingunn M. Stefansson, Audun Braaten, Karin Collett, Lars A. Akslen, Geir Egil Eide, Johan Eide, Turid Aas |
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| Přispěvatelé: | Epigenetic Regulation of Gene Expression (inactive) (SILS, FNWI) |
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty medicine.medical_treatment Breast Neoplasms macromolecular substances Biology Targeted therapy Metastasis Cytokeratin Breast cancer medicine Biomarkers Tumor Humans Enhancer of Zeste Homolog 2 Protein Neoplasm Invasiveness Lymph node Survival analysis Cell Proliferation Analysis of Variance Cell growth EZH2 Polycomb Repressive Complex 2 Middle Aged medicine.disease Immunohistochemistry Survival Analysis DNA-Binding Proteins medicine.anatomical_structure Ki-67 Antigen Oncology Receptors Estrogen Lymphatic Metastasis Cancer research Female Tumor Suppressor Protein p53 Transcription Factors |
| Zdroj: | Clinical Cancer Research, 12, 1168-1174. American Association for Cancer Research Inc. |
| ISSN: | 1078-0432 |
| Popis: | The polycomb group protein enhancer of zeste homologue 2 (EZH2) has been linked to invasive properties of aggressive breast cancer. In this report, tissue microarray analysis of 190 breast carcinomas from a nested case-control study shows that EZH2 is significantly associated with interval breast cancers. Further, a strong relationship was found with tumor cell proliferation (by Ki-67 expression), locally advanced disease, metastasis at presentation, markers of the basal epithelial phenotype (positivity for cytokeratin 5/6 or P-cadherin), and p53 status. EZH2 expression was also significantly associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype. For prediction of aggressive disease (any event of locally advanced disease, lymph node spread, or distant spread), EZH2 was the only variable of significance in multivariate analysis, whereas no additional information was given by Ki-67. Although EZH2 expression was significant in univariate survival analysis, only tumor cell proliferation and lymph node status were significant in the final multivariate model. In conclusion, our findings indicate an important relationship not only between EZH2 and markers of tumor cell proliferation but also with aggressive disease. These findings might be practically important and relevant because the polycomb group proteins have recently been suggested as candidates for targeted therapy. |
| Databáze: | OpenAIRE |
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