Headache in beta-thalassemia: An Italian multicenter clinical, conventional MRI and MR-angiography case-control study
| Autor: | Caterina Maietta, Martina Caiazza, Elisa De Michele, Sara Ponticorvo, Rosanna Di Concilio, Andrea Elefante, Fabrizio Esposito, Immacolata Tartaglione, Angela Ciancio, Camilla Russo, Antonietta Canna, Gianluca Femina, Renzo Manara, Domenico Roberti, Andrea G. Russo, Maddalena Casale, Silverio Perrotta, Mario Cirillo, Maria Sole Valentino, Mario Ermani |
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| Přispěvatelé: | Tartaglione, I., Caiazza, M., Di Concilio, R., Ciancio, A., De Michele, E., Maietta, C., Valentino, M. S., Russo, C., Roberti, D., Casale, M., Elefante, A., Femina, G., Esposito, F., Ponticorvo, S., Russo, A. G., Canna, A., Ermani, M., Cirillo, M., Perrotta, S., Manara, R. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Pediatrics medicine.medical_specialty Adolescent Anemia Population Transfusions 03 medical and health sciences Young Adult 0302 clinical medicine Cognition MR-angiography Brief Psychiatric Rating Scale medicine Brain MRI Humans education Child Molecular Biology education.field_of_study Intelligence quotient business.industry Transfusion beta-Thalassemia Case-control study Headache Beta thalassemia Intracranial Artery Cell Biology Hematology medicine.disease Magnetic Resonance Imaging Hyperintensity 030104 developmental biology Italy Case-Control Studies Molecular Medicine Female Case-Control Studie business Magnetic Resonance Angiography Human 030215 immunology |
| Zdroj: | Blood cells, moleculesdiseases. 81 |
| ISSN: | 1096-0961 |
| Popis: | Objectives A strikingly increased headache prevalence was recently noted in Sri Lankan beta-thalassemia patients, raising several concerns regarding long-term neurological involvement in this condition. Methods We interviewed on headache occurrence and characteristics 102 Italian beta-thalassemia patients and 129 healthy controls. 3T-MRI, MR-angiography, MR-venography, cognitive and psychiatric findings were considered. Results Headache was diagnosed in 39/102 (38.2%) beta-thalassemia patients without significant phenotype-related differences and in 51/129 (39.5%) controls. Patients and controls did not differ significantly regarding episode number (5.9 ± 6.2 vs 5.4 ± 4.4 days/month), subjective severity-score (6.8 ± 1.4 vs 7.1 ± 1.3), age-at-onset (24.3 ± 13.0 vs 19.5 ± 9.6 years) and headache-subtype rate. No main demographic, clinical or laboratory data was associated with headache but female gender. Headache was not associated with white matter lesions (number or maximal diameter), intracranial aneurysms, intracranial artery stenoses or venous sinus thrombosis. Cognitive and psychiatric evaluations were worse in beta-thalassemia, however, headache did not correlate with full-scale Intelligence Quotient (75.4 ± 18.0 vs 76.7 ± 15.3, with and without headache, respectively) or Brief Psychiatric Rating Scale scores (29.1 ± 2.7 vs 28.5 ± 3.4). Conclusions Among Italian beta-thalassemia patients, headache does not seem to be more common or severe than in the general population. In addition, patients with headache do not seem to present increased conventional MRI, MR-angiography and cognitive/psychiatric changes. |
| Databáze: | OpenAIRE |
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