Factors determining the kinetics of a single dose of testosterone in rats
| Autor: | Peter Celec, Mária Malinová, Július Hodosy, Barbora Filová, Daniela Ostatníková, Miroslava Majzunova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Testosterone propionate
medicine.medical_specialty Testosterone Isobutyrate business.industry Kinetics Single application Testosterone (patch) General Biochemistry Genetics and Molecular Biology rats chemistry.chemical_compound depot form Endocrinology chemistry lcsh:Biology (General) kinetics Internal medicine Cognitive research testosterone rapid form Medicine General Agricultural and Biological Sciences business lcsh:QH301-705.5 Hormone |
| Zdroj: | Archives of Biological Sciences, Vol 64, Iss 3, Pp 859-864 (2012) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | The results from different authors regarding testosterone and cognitive research show controversial results. One of the reasons may be the form of testosterone used in the experiment. The aim of our study was to evaluate the testosterone levels in plasma and its kinetics after the single application of either a long-acting or a short-acting form of this hormone. Twenty female and twenty male adult Wistar rats were divided into two groups that were either gonadectomized or not. The two groups were divided into 4 subgroups depending on whether the animals received testosterone propionate or testosterone isobutyrate intramuscularly. Samples for analysis were collected before and at 2, 4, 24, 48, 72, 96 and 168 h after injection. The results showed significant differences in the dynamics between rapid and depot forms of testosterone, together with the rebound effect and hormonal negative feedback. These aspects of testosterone kinetics need to be considered when planning experiments on the physiology of testosterone. |
| Databáze: | OpenAIRE |
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