Cytotoxic Effects of Food Additives and Pharmaceuticals on Cells in Culture as Determined with the Neutral Red Assay
| Autor: | H. Babich, Ellen Borenfreund |
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| Rok vydání: | 1990 |
| Předmět: |
Mice
Inbred BALB C Neutral red Cell Survival Phthalic Acids Butylated Hydroxyanisole Pharmaceutical Science Antineoplastic Agents Butylated Hydroxytoluene In vitro Mice chemistry.chemical_compound chemistry Biochemistry Neutral Red Cell culture Toxicity Animals Humans Phenazines Butylated hydroxytoluene Cytotoxic T cell Food Additives Butylated hydroxyanisole Cytotoxicity Cells Cultured |
| Zdroj: | Journal of Pharmaceutical Sciences. 79:592-594 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600790709 |
| Popis: | The acute cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole to cultured human dermal fibroblasts, keratinocytes, melanocytes, and melanoma tumor cells was determined with the neutral red assay. For all cell types, butylated hydroxytoluene proved to be more cytotoxic than butylated hydroxyanisole. The neutral red assay is a rapid, economical, semiautomated assay that can be used with a variety of cell types in culture to provide quantitated data that can be used to rank test agents according to their potencies. |
| Databáze: | OpenAIRE |
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