Resistance to Lipophilic Cationic Compounds in Multidrug Resistant Leukemia Cells
Autor: | Nili Ramu, Avner Ramu |
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Rok vydání: | 1993 |
Předmět: |
Cancer Research
Leukemia P388 Chemistry Drug Resistance Cationic polymerization Antineoplastic Agents Growth inhibitory Hematology medicine.disease Membrane Potentials Quaternary Ammonium Compounds Multiple drug resistance Mice Structure-Activity Relationship Leukemia Solubility Oncology Biochemistry Molecular size Lipophilicity Tumor Cells Cultured medicine Animals Cell Division |
Zdroj: | Leukemia & Lymphoma. 9:247-253 |
ISSN: | 1029-2403 1042-8194 |
DOI: | 10.3109/10428199309147378 |
Popis: | Previously we have shown that multidrug resistant cells are cross-resistant to certain permanently charged cationic lipophilic compounds. In the present study we extend these observations to additional cationic lipophilic compounds with unrelated chemical structures. Study of the growth inhibitory activity of series of triphenylalkyl-phosphonium and alkyl-ammonium compounds revealed that cross-resistance to these compounds in multidrug resistant P-388 murine leukemia cells, was related to the presence of cationic charge but not to the molecular size/degree of lipophilicity. |
Databáze: | OpenAIRE |
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