Resistance to Lipophilic Cationic Compounds in Multidrug Resistant Leukemia Cells

Autor: Nili Ramu, Avner Ramu
Rok vydání: 1993
Předmět:
Zdroj: Leukemia & Lymphoma. 9:247-253
ISSN: 1029-2403
1042-8194
DOI: 10.3109/10428199309147378
Popis: Previously we have shown that multidrug resistant cells are cross-resistant to certain permanently charged cationic lipophilic compounds. In the present study we extend these observations to additional cationic lipophilic compounds with unrelated chemical structures. Study of the growth inhibitory activity of series of triphenylalkyl-phosphonium and alkyl-ammonium compounds revealed that cross-resistance to these compounds in multidrug resistant P-388 murine leukemia cells, was related to the presence of cationic charge but not to the molecular size/degree of lipophilicity.
Databáze: OpenAIRE