Salicylamide metabolism in acute intermittent porphyria
| Autor: | Chull S. Song, Herbert L. Bonkowsky, Donald P. Tschudy |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male medicine.medical_specialty Glucuronidation Glucuronates Salicylamide Hydroxylation Porphyrias chemistry.chemical_compound Sulfation Internal medicine Salicylamides medicine Humans Pharmacology (medical) In patient Acute intermittent porphyria Pharmacology Sulfates Chemistry Metabolism medicine.disease Endocrinology Acute Disease Female Glucuronide Half-Life medicine.drug |
| Zdroj: | Clinical Pharmacology & Therapeutics. 15:431-435 |
| ISSN: | 0009-9236 |
| Popis: | Salicylamide is metabolized in man by glucuronidation, sulfation, and hydroxylation. It was used to examine these three drug-metaboliZing pathways in patients with acute intermittent porphyria (AIP). The over-all rate of metabolism of salicylamide was significantly reduced in porphyric subjects, with a mean half-life of 103 minutes in comparison to 72 minutes in normals. This was due largely to the reduced rate of conversion to the sulfate and hydroxyl derivatives. Glucuronidation was not significantly different although there was greater individual variation among porphyric subjects. Consequently, subjects with AIP excreted a larger fraction of salicylamide as its glucuronide. This reduction in the rate of hydroxylation may be related to clinical exacerbations precipitated in patients with AIP by drugs metabolized primarily by hydroxylation. |
| Databáze: | OpenAIRE |
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