Chromatin structure in Down's syndrome
| Autor: | V. M. Inshakova, K. N. Fedorova, D. M. Spitkovsky |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Protein Conformation Lymphocyte Normal serum Biology Blood serum Internal medicine Genetics medicine Humans Lymphocytes Child Cells Cultured Genetics (clinical) S syndrome Temperature Molecular medicine Chromatin Peripheral blood Culture Media Blood Nucleoproteins Spectrometry Fluorescence medicine.anatomical_structure Endocrinology Immunology Lymphocyte culture Down Syndrome |
| Zdroj: | Human Genetics. 28:183-189 |
| ISSN: | 1432-1203 0340-6717 |
| DOI: | 10.1007/bf00278543 |
| Popis: | In the chromatin of patients with Down's syndrome, changes are shown to occur in a short-term lymphocyte culture of the human peripheral blood. Some of them are induced by the patient's blood serum and are reversible when this is replaced by normal serum. A 100-fold dilution of the blood serum taken in subjects with Down's syndrome does not produce any changes in the structure of the lymphocyte chromatin of the patients. A similar procedure with the blood serum of healthy donors resulted in a drastic activation of their lymphocyte chromatin. These experiments, and investigations on the effect produced by the blood serum on the model desoxyribonucleoprotein systems, support the suggestion that the changed state of the chromatin in subjects with Down's syndrome is caused by a complex set of components contained in the blood serum, whose degree of dissociation deviates from the normal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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