Application of Pd-Catalyzed C-H Alkylation Reaction in Total Syntheses of Twelve Amicoumacin-Type Natural Products
| Autor: | Gao-Feng Yin, Xiaodong Wang, Tao Shi, Hui-Hong Wang, Zhen Wang, Zhao Li, Yiyue Feng, Dian He |
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| Rok vydání: | 2021 |
| Předmět: |
Biological Products
Alkylation Molecular Structure Chemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element Biochemistry Combinatorial chemistry Catalysis Normal cell Catalytic oxidation Coumarins Amine gas treating Physical and Theoretical Chemistry Cytotoxicity Oxidation-Reduction Palladium |
| Zdroj: | Organic letters. 23(17) |
| ISSN: | 1523-7052 |
| Popis: | Enantioselective total syntheses of 12 amicoumacin-type natural products are accomplished with a palladium(II)-catalyzed C-H alkylation as the key step to furnish the 3,4-dihydroisocoumarin scaffold. The target chemicals are assembled in a convergent protocol by merging 3,4-dihydroisocoumarin derived amine part with categories of acid segments that are efficiently prepared by chemoselective catalytic oxidation of chiral 1,2-dihydroxyethylfuran-2(5H)-ones. Afterward, the cytotoxicity of amicoumacins on five cancer cell lines and one normal cell line is investigated. |
| Databáze: | OpenAIRE |
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