Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study
| Autor: | Robert D. Sanders, Tyler Ballweg, Amber Bo, Kaj Blennow, Richard Lennertz, Cameron Casey, Henrik Zetterberg, Margaret Parker, Alexander Blair, Zahra Farahbakhsh, Robert A. Pearce, Austin Kayser, Marissa White, Heidi Lindroth |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Time Factors tau Proteins Severity of Illness Index behavioral disciplines and activities Postoperative Complications Neuroscience and Neuroanaesthesia Predictive Value of Tests Internal medicine Glial Fibrillary Acidic Protein mental disorders medicine Humans Prospective Studies Biomarker Analysis Aged Glial fibrillary acidic protein biology business.industry Incidence Incidence (epidemiology) Interleukin-8 Delirium Perioperative nervous system diseases Clinical trial Anesthesiology and Pain Medicine nervous system biology.protein Biomarker (medicine) Female medicine.symptom business Biomarkers Cohort study |
| Zdroj: | Br J Anaesth |
| ISSN: | 0007-0912 |
| DOI: | 10.1016/j.bja.2020.08.061 |
| Popis: | BACKGROUND: Postoperative delirium is associated with increases in the neuronal injury biomarker, neurofilament light (NfL). Here we tested whether two other biomarkers, glial fibrillary acidic protein (GFAP) and tau, are associated with postoperative delirium. METHODS: A total of 114 surgical patients were recruited into two prospective biomarker cohort studies with assessment of delirium severity and incidence. Plasma samples were sent for biomarker analysis including tau, NfL, and GFAP, and a panel of 10 cytokines. We determined a priori to adjust for interleukin-8 (IL-8), a marker of inflammation, when assessing associations between biomarkers and delirium incidence and severity. RESULTS: GFAP concentrations showed no relationship to delirium. The change in tau from preoperative concentrations to postoperative Day 1 was greater in patients with postoperative delirium (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|