Anti-RNA binding protein positivity in idiopathic interstitial pneumonia
| Autor: | Iazsmin Bauer Ventura, Cathryn Lee, Mary E. Strek, Justin M. Oldham, Steven M. Montner, Imre Noth, Ayodeji Adegunsoye, Rekha Vij, Rene S. Bermea, Jonathan H. Chung |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male endocrine system medicine.medical_specialty Hypertension Pulmonary Autoimmunity Gastroenterology Pulmonary function testing FEV1/FVC ratio Internal medicine medicine Prevalence Humans Idiopathic Interstitial Pneumonias Connective Tissue Diseases Idiopathic interstitial pneumonia Lung Aged Retrospective Studies business.industry Interstitial lung disease Middle Aged medicine.disease Pulmonary hypertension Connective tissue disease respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Antibodies Antinuclear Cohort Female Radiography Thoracic business Carrier Proteins Tomography X-Ray Computed |
| Zdroj: | Respiratory medicine. 146 |
| ISSN: | 1532-3064 |
| Popis: | INTRODUCTION Idiopathic interstitial pneumonias (IIP) are diffuse lung diseases whose cause is unknown and often present with features of autoimmunity despite not meeting criteria for a connective tissue disease (CTD). Recent studies suggest that anti-RNA binding protein (anti-RBP) antibodies, which include anti-SSA, anti-SSB, anti-Sm, and anti-RNP, play a role in the loss of immune tolerance and severity of pulmonary hypertension (PH) in CTDs. We hypothesized that anti-RBP positive (RBP+) subjects would have worse measures of lung function, radiographic findings, PH, and survival than anti-RBP negative (RBP-) subjects. METHODS Subjects with both IIP and serologies for review were identified retrospectively and stratified based on anti-RBP antibody seropositivity. Baseline cohort characteristics, pulmonary function tests (PFT), ambulatory oxygen requirement, radiographic characteristics, markers of PH, and transplant-free survival were compared between anti-RBP positive and negative groups. RESULTS Five hundred twenty patients with IIP were identified, of which ten percent (n = 53) were anti-RBP positive. RBP+ as compared to RBP- subjects had significantly worse PFTs as indicated by FEV1 (59.6 vs. 64.9, p = 0.046) and FVC (71.6 vs. 78.8, p = 0.018). There was a higher prevalence of radiographic honeycombing (49.1% vs. 38.3%, p = 0.006) and emphysema (22.6% vs. 5.1%, p |
| Databáze: | OpenAIRE |
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