Combination Antibiotics Improves Disease Activity and Alters Microbial Communities in Children With Ulcerative Colitis
| Autor: | Nicole J Cunningham, Kattayoun Kordy, David J. Lee, Fan Li, Anna Claudia Romeo, Monica Saavedra, Nicole H. Tobin, Sara Zabih, Grace M. Aldrovandi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent medicine.drug_class Antibiotics Gut flora Gastroenterology Inflammatory bowel disease Article Young Adult 03 medical and health sciences 0302 clinical medicine Vancomycin Metronidazole Internal medicine medicine Humans Young adult Colitis Child Fluconazole Retrospective Studies biology business.industry Amoxicillin Retrospective cohort study medicine.disease biology.organism_classification Ulcerative colitis Anti-Bacterial Agents Gastrointestinal Microbiome Regimen 030104 developmental biology Doxycycline Pediatrics Perinatology and Child Health Colitis Ulcerative Female 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 67:e60-e63 |
| ISSN: | 1536-4801 0277-2116 |
| Popis: | Combinations of antibiotics have shown promise in off-label treatment of Inflammatory Bowel Disease (IBD) flares in adult and pediatric patients1–6. In a small pediatric cohort of moderate-severe medically refractory Ulcerative Colitis (UC), half achieved remission with a regimen of 3–4 antibiotics6. The rationale is to decrease mucosal inflammation by altering intestinal microbiota, however, to date no study has documented these changes. We report our experience with combination oral antibiotics in symptomatic pediatric patients with steroid-dependent or -resistant UC, and demonstrate significant alterations in gut microbiota during and after antibiotic therapy with reductions in inflammatory markers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text