Drug-Smectite Clay Amorphous Solid Dispersions Processed by Hot Melt Extrusion

Autor: Uttom Nandi, Md. S.H. Mithu, Vivek Trivedi, Dennis Douroumis, Andrew P. Hurt
Rok vydání: 2020
Předmět:
Materials science
Drug Compounding
Indomethacin
Pharmaceutical Science
chemistry.chemical_element
02 engineering and technology
Aquatic Science
030226 pharmacology & pharmacy
RS
Excipients
03 medical and health sciences
0302 clinical medicine
Differential scanning calorimetry
Drug Stability
X-Ray Diffraction
Drug Discovery
Spectroscopy
Fourier Transform Infrared
Dissolution testing
Dissolution
Ecology
Evolution
Behavior and Systematics
Drug Carriers
Ecology
Calorimetry
Differential Scanning
Magnesium
Silicates
Anti-Inflammatory Agents
Non-Steroidal
Hot Melt Extrusion Technology
General Medicine
021001 nanoscience & nanotechnology
Amorphous solid
Drug Liberation
chemistry
Chemical engineering
Solubility
Extrusion
0210 nano-technology
Dispersion (chemistry)
Clay minerals
Agronomy and Crop Science
Powder Diffraction
Zdroj: AAPS PharmSciTech. 21(7)
ISSN: 1530-9932
Popis: The aim of this study was to investigate suitability of natural and synthetic smectite clay matrices as a drug delivery carrier for the development of amorphous solid dispersions (ASD). Indomethacin (IND) was processed with two different smectite clays, natural-magnesium aluminium and synthetic-lithium magnesium sodium silicates, using Hot Melt Extrusion (HME) to prepare solid dispersions. Scanning electron microscopy (SEM), Powdered X-ray diffraction (PXRD), Differential scanning calorimetry (DSC) were used to examine the physical form of the drug. Energy dispersive X-ray spectroscopy (EDX) was used to investigate the drug distribution and Attenuated Total Reflectance-Fourier transform infrared (ATR-FTIR) spectroscopic analysis was done to detect any chemical interaction between these two kinds. Both, PXRD and DSC analysis showed that drug-clay solid dispersion contained IND in amorphous form. Energy dispersive X-ray (EDX) analysis showed a uniform IND dispersion in the extruded powders. ATR-FTIR data presented possible drug and clay interactions via hydrogen bonding. In-vitro drug dissolution studies revealed a lag time of about two hours in the acidic media and a rapid release of IND at pH 7.4. The work demonstrated that preparation of amorphous solid dispersion using inorganic smectite clay particles can effectively increase the dissolution rate of IND.
Databáze: OpenAIRE
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