IL-10 is pathogenic during the development of coxsackievirus B4-induced chronic pancreatitis
| Autor: | Andrew A. Reilly, Rui Gu, Anae Shampang, Arlene I. Ramsingh, Dusti Fisher, William G. Glass |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Transcriptional profiling Regulatory T cell T cell Coxsackievirus Infections Biology Coxsackievirus Virus Replication T-Lymphocytes Regulatory Article Th1 Mice Th2 Immune system Pancreatitis Chronic TLR Virology medicine Animals Pancreatitis chronic Pancreas Mice Knockout Mice Inbred BALB C Innate immune system Gene Expression Profiling Viral Load biology.organism_classification medicine.disease Enterovirus B Human Interleukin-10 Interleukin 10 medicine.anatomical_structure Pancreatitis IL-10 Immunology Cytokines Female Th17 Signal Transduction |
| Zdroj: | Virology. 395(1):77-86 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2009.09.005 |
| Popis: | Using a mouse model of coxsackievirus B4 (CVB4-V)-induced chronic pancreatitis, we investigated whether cytokines are involved in the progression of acute disease to chronic inflammatory disease. We show that IL-10 contributed to the development of chronic pancreatitis since acute disease resolved when IL-10 was absent or when IL-10 signaling was disrupted. We explored the underlying mechanisms by which IL-10 affected disease progression, using a novel approach to assess immunological events occurring in situ. Multiple markers that define functional innate immune responses and functional T cell responses were monitored over the course of CVB4-V infection of wild-type and IL-10 knockout mice, using a multiplex transcriptional profiling approach. We show that high levels of IL-10 early during infection were associated with delayed innate and T cell responses. Furthermore, high IL-10 production correlated with altered kinetics of T regulatory responses indicating a disruption in the balance between effector and regulatory T cell responses. |
| Databáze: | OpenAIRE |
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