Effect of Peripheral Electrical Stimulation (PES) on Nocturnal Blood Glucose in Type 2 Diabetes: A Randomized Crossover Pilot Study

Autor: Shai Efrati, Merav Catalogna, Ramzia Abu-Hamad, Keren Doenyas-Barak, Eshel Ben-Jacob, Roi Sagi, Uri Nevo
Rok vydání: 2016
Předmět:
Blood Glucose
Male
Hydrocortisone
Physiology
Peptide Hormones
medicine.medical_treatment
lcsh:Medicine
Type 2 diabetes
Biochemistry
Gastroenterology
Endocrinology
0302 clinical medicine
Medicine and Health Sciences
Insulin
Medicine
Glucose homeostasis
Lipid Hormones
lcsh:Science
Cross-Over Studies
Multidisciplinary
Organic Compounds
Glucose meter
Monosaccharides
Hematology
Middle Aged
Blood Sugar
Type 2 Diabetes
Body Fluids
Chemistry
Blood
Tolerability
Physical Sciences
Female
Anatomy
Research Article
medicine.medical_specialty
Endocrine Disorders
Carbohydrates
Blood sugar
Electric Stimulation Therapy
Surgical and Invasive Medical Procedures
030209 endocrinology & metabolism
03 medical and health sciences
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Humans
Aged
Diabetic Endocrinology
Steroid Hormones
Functional Electrical Stimulation
business.industry
Organic Chemistry
lcsh:R
Chemical Compounds
Biology and Life Sciences
Glucagon
medicine.disease
Crossover study
Hormones
Surgery
Glucose
Diabetes Mellitus
Type 2
Metabolic Disorders
lcsh:Q
business
030217 neurology & neurosurgery
Zdroj: PLoS ONE, Vol 11, Iss 12, p e0168805 (2016)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0168805
Popis: Background Regulation of hepatic glucose production has been a target for antidiabetic drug development, due to its major contribution to glucose homeostasis. Previous pre-clinical study demonstrated that peripheral electrical stimulation (PES) may stimulate glucose utilization and improve hepatic insulin sensitivity. The aim of the present study was to evaluate safety, tolerability, and the glucose-lowering effect of this approach in patients with type 2 diabetes (T2DM). Methods Twelve patients with T2DM were recruited for an open label, interventional, randomized trial. Eleven patients underwent, in a crossover design, an active, and a no-intervention control periods, separated with a two-week washout phase. During the active period, the patients received a daily lower extremity PES treatment (1.33Hz/16Hz burst mode), for 14 days. Study endpoints included changes in glucose levels, number of hypoglycemic episodes, and other potential side effects. Endpoints were analyzed based on continuous glucose meter readings, and laboratory evaluation. Results We found that during the active period, the most significant effect was on nocturnal glucose control (P < 0.0004), as well as on pre-meal mean glucose levels (P < 0.02). The mean daily glucose levels were also decreased although it did not reach clinical significance (P = 0.07). A reduction in serum cortisol (P < 0.01) but not in insulin was also detected after 2 weeks of treatment. No adverse events were recorded. Conclusions These results indicate that repeated PES treatment, even for a very short duration, can improve blood glucose control, possibly by suppressing hepatic glucose production. This effect may be mediated via hypothalamic-pituitary-adrenal axis modulation. Trial registration ClinicalTrials.gov NCT02727790
Databáze: OpenAIRE
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