Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
| Autor: | Teresa Padró, Doris Wenning, Matthias Kroger, Wolfgang E. Berdel, Rolf M. Mesters, Christian Scheffold, Berno Dankbar, R. Leo, Guido Bisping, Martin Kropff, Joachim Kienast |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Stromal cell Angiogenesis medicine.medical_treatment Immunology Basic fibroblast growth factor Bone Marrow Cells Fibroblast growth factor Biochemistry Paracrine signalling chemistry.chemical_compound Internal medicine Paracrine Communication Medicine Humans Multiple myeloma Dose-Response Relationship Drug business.industry Interleukin-6 Cell Biology Hematology medicine.disease Receptors Fibroblast Growth Factor Coculture Techniques Up-Regulation Endocrinology Cytokine medicine.anatomical_structure chemistry Case-Control Studies Cancer research Fibroblast Growth Factor 2 Bone marrow Stromal Cells business Multiple Myeloma |
| Zdroj: | Blood. 101(7) |
| ISSN: | 0006-4971 |
| Popis: | Myeloma cells express basic fibroblast growth factor (bFGF), an angiogenic cytokine triggering marrow neovascularization in multiple myeloma (MM). In solid tumors and some lymphohematopoietic malignancies, angiogenic cytokines have also been shown to stimulate tumor growth via paracrine pathways. Since interleukin-6 (IL-6) is a potent growth and survival factor for myeloma cells, we have studied the effects of bFGF on IL-6 secretion by bone marrow stromal cells (BMSCs) and its potential reverse regulation in myeloma cells. Both myeloma-derived cell lines and myeloma cells isolated from the marrow of MM patients were shown to express and secrete bFGF. Cell-sorting studies identified myeloma cells as the predominant source of bFGF in MM marrow. BMSCs from MM patients and control subjects expressed high-affinity FGF receptors R1 through R4. Stimulation of BMSCs with bFGF induced a time- and dose-dependent increase in IL-6 secretion (median, 2-fold; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|