The effect of asparagine and adenine on the glutamine requirement for growth of human peripheral lymphocytes

Autor:	Flora H. Pettit, William Shive, Jocelyne O. Boghossian
Rok vydání:	1989
Předmět:	Purine Cell growth Adenine Glutamine Lymphocyte Biophysics Cell Biology Biology Biochemistry Kinetics chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Humans Lymphocytes Asparagine Purine metabolism Molecular Biology Cell Division Cells Cultured
Zdroj:	Biochemical and Biophysical Research Communications. 164:1348-1351
ISSN:	0006-291X
DOI:	10.1016/0006-291x(89)91817-2
Popis:	Quantitative growth responses of lymphocytes directly isolated from individual subjects in a newly developed chemically-defined, protein-free medium are used to demonstrate that supplements of both L-asparagine and a purine source, but neither alone, significantly reduce the quantitative requirement for L-glutamine for growth. This system is useful for exploring individual differences in quantitative glutamine requirements and adequacy of asparagine and purine biosynthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02bea76b2b0a7d9c999b9b492752dee https://doi.org/10.1016/0006-291x(89)91817-2 Zobrazit plný text záznamu