Chronic ethanol exposure during adolescence impairs simple spike activity of cerebellar Purkinje cells in vivo in mice

Autor:	Guang-Hui Dong, Yin-Hua Xu, Liang-Yan Liu, Di Lu, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu
Rok vydání:	2021
Předmět:	Male Mice Inbred ICR Ethanol General Neuroscience Neurogenesis Action Potentials Brain Central Nervous System Depressants Receptors N-Methyl-D-Aspartate Mice Purkinje Cells Animals Female GABA-A Receptor Antagonists
Zdroj:	Neuroscience letters. 771
ISSN:	1872-7972
Popis:	Cerebellar Purkinje cells (PCs) play critical roles in motor coordination and motor learning through their simple spike (SS) activity. Previous studies have shown that chronic ethanol exposure (CEE) in adolescents impairs learning, attention, and behavior, at least in part by impairing the activity of cerebellar PCs. In this study, we investigated the effect of CEE on the SS activity in urethane-anesthetized adolescent mice by in vivo electrophysiological recordings and pharmacological methods. Our results showed that the cerebellar PCs in CEE adolescent mice expressed a significant decrease in the frequency and an increase in the coefficient of variation (CV) of SS than control group. Blockade of ɤ-aminobutyric acid A (GABA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02b3132b0f26272569e285a03743b27 https://pubmed.ncbi.nlm.nih.gov/34919990 Zobrazit plný text záznamu Full Text from ScienceDirect