Features of Lipoperoxidation, Antioxidant Defense, and Thiol/Disulfide System in the Pathogenesis of Infertility in Males, Carriers of Nonfunctional Variants of GSTT1 and GSTM1 Gene Polymorphisms

Autor: N. V. Koroleva, M. I. Dolgikh, N A Kurashova, O. A. Ershova, L. I. Kolesnikova, I. N. Gutnik, T. A. Bairova, B. G. Dashiev, L. V. Natyaganova
Rok vydání: 2016
Předmět:
Infertility
Adult
Male
medicine.medical_specialty
Heterozygote
Antioxidant
medicine.medical_treatment
Gene Expression
Biology
medicine.disease_cause
Thiobarbituric Acid Reactive Substances
General Biochemistry
Genetics and Molecular Biology
Antioxidants
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Gene Frequency
Internal medicine
Blood plasma
medicine
Humans
Genetic Predisposition to Disease
Alleles
Infertility
Male
Glutathione Transferase
chemistry.chemical_classification
Glutathione Peroxidase
030219 obstetrics & reproductive medicine
Polymorphism
Genetic
General Medicine
Glutathione
medicine.disease
Spermatozoa
Semen Analysis
Endocrinology
Enzyme
Glutathione Reductase
chemistry
Case-Control Studies
Thiol
Lipid Peroxidation
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Bulletin of experimental biology and medicine. 163(3)
ISSN: 1573-8221
Popis: Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studies. A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes. In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed. Identification of carriers the polymorphic GSTT1 and GSTM1 variants and analysis of activity of the thiol/disulfide system enzymes can be recommended for additional evaluation of the risk for reproductive dysfunction in men.
Databáze: OpenAIRE
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