Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis
| Autor: | Fernando Gómez-Chávez, Isaí Martínez-Torres, Azael Torales-Cardeña, Juan C. Cancino-Diaz, Sandra Rodríguez-Martínez, Ernesto Antonio Vázquez-Sánchez, Mario E. Cancino-Diaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Vascular Endothelial Growth Factor A
Angiogenesis Immunology Neovascularization Physiologic Inflammation Review Article Biology Pathogenesis Neovascularization Mice Immune system Psoriasis medicine lcsh:Pathology Animals Humans Transcription factor Cell Proliferation Cell Polarity Cell Biology medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Vascular endothelial growth factor A Disease Models Animal Cytokines Th17 Cells medicine.symptom Interleukin-1 lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2015 (2015) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor “hypoxia-inducible factor 1-alpha” (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1αin the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed. |
| Databáze: | OpenAIRE |
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