Predictors of oncological outcomes in T1G3 patients treated with BCG who undergo radical cystectomy

Autor: Paolo Gontero, Jennifer Irani, J. Varkarakis, S. M. Di Stasi, Guido Dalbagni, Eugene K. Cha, E.N. Xylinas, Viktor Soukup, Vincenzo Serretta, Renzo Colombo, T. Tony Cai, Núria Malats, S. Joniau, Anne J. Grotenhuis, Per-Uno Malmström, Roy Mano, S. Larrè, Marek Babjuk, Richard Sylvester, Alberto Briganti, R. Bartoletti, Jack Baniel, S.F. Shariat, Juan Palou, P. Ardelt, Francesca Pisano, J.A. Witjes, Robert Jeffrey Karnes, Francesco Soria, B.W.G. Van Rhijn
Přispěvatelé: Soria, Francesco, Pisano, Francesca, Gontero, Paolo, Palou, J, Joniau, S, Serretta, V, Larré, S, Di Stasi, S, van Rhijn, B, Witjes, J A, Grotenhuis, A, Colombo, R, Briganti, A, Babjuk, M, Soukup, V, Malmstrom, P U, Irani, J, Malats, N, Baniel, J, Mano, R, Cai, T, Cha, E, Ardelt, P, Varkarakis, J, Bartoletti, R, Dalbagni, G, Shariat, S F, Xylinas, E, Karnes, R J, Sylvester, R, Soria, F., Pisano, F., Gontero, P., Palou, J., Joniau, S., Serretta, V., Larre, S., Di Stasi, S., van Rhijn, B., Witjes, J. A., Grotenhuis, A., Colombo, R., Briganti, A., Babjuk, M., Soukup, V., Malmstrom, P. U., Irani, J., Malats, N., Baniel, J., Mano, R., Cai, T., Cha, E., Ardelt, P., Varkarakis, J., Bartoletti, R., Dalbagni, G., Shariat, S. F., Xylinas, E., Karnes, R. J., Sylvester, R.
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Nephrology
Male
medicine.medical_treatment
030232 urology & nephrology
Kaplan-Meier Estimate
Settore MED/24 - Urologia
Cohort Studies
0302 clinical medicine
Retrospective Studie
Multivariate Analysi
Outcome
education.field_of_study
High risk
Bladder cancer
Middle Aged
Prognosis
Editorial
Treatment Outcome
Local
030220 oncology & carcinogenesis
BCG Vaccine
Female
Survival Analysi
Cystectomy
Extravesical disease
Outcomes
T1G3
Urology
Human
medicine.medical_specialty
Prognosi
Population
Risk Assessment
Disease-Free Survival
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Internal medicine
Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]
medicine
Humans
Neoplasm Invasiveness
education
Survival analysis
Proportional Hazards Models
Retrospective Studies
Aged
Neoplasm Staging
Neoplasm Invasivene
Carcinoma
Transitional Cell
business.industry
Proportional hazards model
Multivariate Analysis
Neoplasm Recurrence
Local
Survival Analysis
Urinary Bladder Neoplasms
Carcinoma
Retrospective cohort study
medicine.disease
Neoplasm Recurrence
Concomitant
Proportional Hazards Model
Transitional Cell
Cohort Studie
business
Zdroj: Translational Andrology and Urology
World Journal of Urology, 36, 11, pp. 1775-1781
WORLD JOURNAL OF UROLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
World Journal of Urology, 36, 1775-1781
ISSN: 0724-4983
Popis: PURPOSE: To evaluate the oncological impact of postponing radical cystectomy (RC) to allow further conservative therapies prior to progression in a large multicentre retrospective cohort of T1-HG/G3 patients initially treated with BCG. METHODS: According to the time of RC, the population was divided into 3 groups: patients who did not progress to muscle-invasive disease, patients who progressed before radical cystectomy and patients who experienced progression at the time of radical cystectomy. Clinical and pathological outcomes were compared across the three groups. RESULTS: Of 2451 patients, 509 (20.8%) underwent RC. Patients with tumors > 3 cm or with CIS had earlier cystectomies (HR = 1.79, p = 0.001 and HR = 1.53, p = 0.02, respectively). Patients with tumors > 3 cm, multiple tumors or CIS had earlier T3/T4 or N + cystectomies. In patients who progressed, the timing of cystectomy did not affect the risk of T3/T4 or N + disease at RC. Patients with T3/T4 or N + disease at RC had a shorter disease-specific survival (HR = 4.38, p
Databáze: OpenAIRE
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