Macromolecules inhibit calcium oxalate crystal growth and aggregation in whole human urine
| Autor: | K. A. Edyvane, C. M. Hibberd, R. M. Harnett, Rosemary L. Ryall, Villis R. Marshall |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Calcium Oxalate
Chemistry Macromolecular Substances Biochemistry (medical) Clinical Biochemistry Inorganic chemistry Calcium oxalate Nucleation chemistry.chemical_element Crystal growth General Medicine Urine Calcium medicine.disease Biochemistry Crystal chemistry.chemical_compound Kidney Calculi Kidney stone disease medicine Biophysics Chemical Precipitation Humans Crystallization Macromolecule |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 167(3) |
| ISSN: | 0009-8981 |
| Popis: | Removal of macromolecules with Mr greater than 10000 had no discernible effect on the detectable nucleation of calcium oxalate crystals from undiluted human urine, but promoted the deposition of crystalline material and markedly increased the degree of aggregation of the precipitated crystals. Calcium oxalate crystals and crystal aggregates precipitated from ultrafiltered urine were, on average, 68% larger than those deposited from whole urine. These findings suggest that urinary macromolecules play a key role in preventing calcium oxalate kidney stone disease by inhibiting the formation of large crystal aggregates and thereby reducing the probability of particle retention in the kidney tubules. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|