Effect of some antioxidants on oxidative DNA damage induced by autoxidation of microquantities of sulfite in the presence of Ni(II)/Gly–Gly–L–His

Autor:	María V. Alipázaga, Nina Coichev, Horacio Dorigan Moya
Rok vydání:	2010
Předmět:	Autoxidation chemistry.chemical_element Resveratrol Green tea Medicinal chemistry Oxidative dna damage Melatonin chemistry.chemical_compound Nickel NÍQUEL Sulfite chemistry Materials Chemistry medicine Organic chemistry Physical and Theoretical Chemistry DNA medicine.drug
Zdroj:	Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP
ISSN:	1029-0389 0095-8972
DOI:	10.1080/00958972.2010.491544
Popis:	NiIIGGH (GGH, glycylglycyl-L-histidine) reacts rapidly with S(IV), in air-saturated solution, to produce NiIIIGGH. A mechanism is proposed where NiIII oxidizes to , which reacts with dissolved oxygen to produce , initiating radical chain reactions. DNA strand breaks and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) formation were observed in air-saturated solutions containing micromolar concentrations of nickel(II) and S(IV). The efficacies of melatonin, (−)-epigallocatechin-gallate (from green tea), resveratrol, tannic, and ascorbic acids in terms of their inhibitory activities of DNA strand breaks and 8-oxodGuo formation were evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f024f19abb328c3a3bfefa22de94b0c9 https://doi.org/10.1080/00958972.2010.491544 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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