Predictors of Over-Reporting HIV Pre-exposure Prophylaxis (PrEP) Adherence Among Young Men Who Have Sex With Men (YMSM) in Self-Reported Versus Biomarker Data

Autor: Zoe Baker, Pamina M. Gorbach, Michelle Lally, Stan Mierzwa, Craig Pavel, Marjan Javanbakht, Gregory D. Zimet
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Human immunodeficiency virus (HIV)
HIV Infections
Adolescents
medicine.disease_cause
Men who have sex with men
Pre-exposure prophylaxis
0302 clinical medicine
Surveys and Questionnaires
030212 general & internal medicine
African Americans
Homosexuality
Infectious Diseases
Public Health and Health Services
HIV/AIDS
Biomarker (medicine)
Public Health
Random intercept
Social Work
medicine.medical_specialty
Adolescent
Social Psychology
Article
Medication Adherence
Odds
Young Adult
03 medical and health sciences
Clinical Research
Behavioral and Social Science
medicine
Humans
Homosexuality
Male
business.industry
Prevention
Public health
Racial Groups
Public Health
Environmental and Occupational Health
HIV
Repeated measures design
030112 virology
Black or African American
Good Health and Well Being
Adherence
Pre-Exposure Prophylaxis
Self Report
business
Biomarkers
Demography
Zdroj: AIDS and behavior, vol 22, iss 4
ISSN: 1573-3254
1090-7165
DOI: 10.1007/s10461-017-1958-4
Popis: Young men who have sex with men (YMSM) face a disproportionately high burden of HIV. Oral pre-exposure prophylaxis (PrEP) is effective in preventing HIV acquisition, but adherence to PrEP among YMSM may be inadequate. Medication adherence may be assessed via biomarkers, which are expensive and invasive, or via self-report through Audio Computer Assisted Self-Interview (ACASI), which may result in over-reporting of adherence. In this paper we assess the potential of a new method of self-report, the Interactive Questionnaire System (iQS), in validly estimating true adherence rates. PrEP adherence among 167 YMSM aged 15-23 was measured via dried blood spot (DBS), ACASI, and iQS twice over a 24-week study period. Both ACASI- and iQS-reported data revealed that over 40% of individuals self-reporting adequate PrEP adherence had DBS-estimated drug levels indicating inadequate adherence. Adjusted logistic repeated measures random intercept regression analyses indicated that younger YMSM had higher odds of over-reporting adherence than older YMSM-each 1year increase in age was associated with 0.79 times the odds of over-reporting adherence (95% CI 0.63, 0.98; p value=0.031), and being African American was associated with 3.22 times greater odds of over-reporting than non-African Americans (95% CI 1.51, 6.90; p-value=0.0003). These results suggest that ACASI and iQS methods of self-report significantly overestimate true PrEP adherence rates among YMSM, and that the odds of over-reporting adherence may be affected by both age and race.
Databáze: OpenAIRE
Externí odkaz: