Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones
| Autor: | Naomu Miyamae, Yoshiyasu Ichikawa, Maya Moritaka, Naruhisa Watanabe, Keiji Nakano, Hiyoshizo Kotsuki |
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| Rok vydání: | 2014 |
| Předmět: |
Primary (chemistry)
Chemistry Proton Magnetic Resonance Spectroscopy Organic Chemistry Chemistry Organic Enantioselective synthesis Stereoisomerism Biochemistry Desymmetrization Catalysis High pressure Cyclohexenes Pressure Solvents Michael reaction Organic chemistry Physical and Theoretical Chemistry Conjugate |
| Zdroj: | Org. Biomol. Chem.. 12:5847-5855 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | A highly diastereoselective and enantioselective method for the asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones using the Michael addition reaction of malonates under catalysis with the primary amine-thiourea conjugate catalyst and PPY at high pressure was developed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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