Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

Autor: Veselina Uzunova, Borislava Borisova, Albena Momchilova, Roumen Pankov, Tihomira Stoyanova, Rumiana Tzoneva, Liliana Maslenkova
Rok vydání: 2021
Předmět:
Zdroj: Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 853-861 (2021)
ISSN: 1314-3530
1310-2818
Popis: In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction in viability with concomitant increase of apoptosis in human breast cancer cells after 72 h treatment. We found the highest cytotoxicity of BE to MDA-MB-231 cells (IC50 – 520 μg/mL), followed by the MCF-7 cancer cell line (IC50 – 865 μg/mL). At the same time, the extract exhibited very low cytotoxicity to the non-tumorigenic L929 cell line (two-fold higher inhibitory concentration – 1252 μg/mL). As a result of our experiments we made the conclusion that Butterbur root extract shows selective high cytotoxicity and nucleus alterations in cancer cells comparing to non-cancerous cells.
Databáze: OpenAIRE
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