Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines
| Autor: | Veselina Uzunova, Borislava Borisova, Albena Momchilova, Roumen Pankov, Tihomira Stoyanova, Rumiana Tzoneva, Liliana Maslenkova |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0303 health sciences biology Traditional medicine apoptosis petasites hybridus Cancer biology.organism_classification medicine.disease 01 natural sciences 03 medical and health sciences PETASITES HYBRIDUS ROOT Breast cancer cell line Apoptosis Cancer cell cancer cells Petasites hybridus medicine cytotoxicity Breast cancer cells Cytotoxicity TP248.13-248.65 030304 developmental biology 010606 plant biology & botany Biotechnology |
| Zdroj: | Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 853-861 (2021) |
| ISSN: | 1314-3530 1310-2818 |
| Popis: | In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction in viability with concomitant increase of apoptosis in human breast cancer cells after 72 h treatment. We found the highest cytotoxicity of BE to MDA-MB-231 cells (IC50 – 520 μg/mL), followed by the MCF-7 cancer cell line (IC50 – 865 μg/mL). At the same time, the extract exhibited very low cytotoxicity to the non-tumorigenic L929 cell line (two-fold higher inhibitory concentration – 1252 μg/mL). As a result of our experiments we made the conclusion that Butterbur root extract shows selective high cytotoxicity and nucleus alterations in cancer cells comparing to non-cancerous cells. |
| Databáze: | OpenAIRE |
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