Mycophenolate Mofetil-related Pancolitis in a Kidney Transplant Recipient
| Autor: | Houda Mahmoudi, Mouna Hamouda, Habib Skhiri, Mezri Elmay |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Diarrhea Graft Rejection Male Pancolitis medicine.medical_specialty Cryptitis Colonoscopy Mycophenolate Gastroenterology Organ transplantation Internal medicine medicine Humans Colitis Adverse effect Kidney transplantation Transplantation medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Mycophenolic Acid medicine.disease Kidney Transplantation medicine.symptom business |
| Zdroj: | Experimental and Clinical Transplantation. 10:501-505 |
| ISSN: | 2146-8427 1304-0855 |
| Popis: | Gastrointestinal adverse effects are common with mycophenolate mofetil administration, especially diarrhea. We report a case of mycophenolate mofetil-related colitis in a kidney transplant recipient. Colonoscopy revealed an ulcerative diffuse colitis. The colonoscopic biopsy specimen showed mild crypt distortion, accompanied by cryptitis and focal graft-versus-host disease like changes. The patient's symptoms improved after we discontinued the mycophenolate mofetil. A repeat colonoscopy 2 months after we discontinued the mycophenolate mofetil showed reparative changes. Mycophenolate mofetil is an important drug in organ transplant immune-suppression regimens; however, with its widespread use, additional adverse effects continue to be recognized. |
| Databáze: | OpenAIRE |
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