Rhodium-Catalyzed Directed C–H Amidation of Imidazoheterocycles with Dioxazolones

Autor:	Susmita Mondal, Debashis Ghosh, Sadhanendu Samanta, Alakananda Hajra
Rok vydání:	2019
Předmět:	010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry Cleavage (embryo) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Rhodium Catalysis chemistry.chemical_compound chemistry Reagent Physical and Theoretical Chemistry Acetamide
Zdroj:	Organic Letters. 21:4905-4909
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.9b01832
Popis:	A Rh(III)-catalyzed directed ortho-amidation of 2-arylimidazoheterocycles using dioxazolone as an amidating reagent has been developed. This protocol is a simple, straightforward, and economic was to afford a variety of N-(2-(imidazo[1,2- a]pyridin-2-yl)phenyl)acetamide derivatives with excellent yields. A mechanistic study reveals that a reversible cleavage of C-H bond might be involved in the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01e6684e1ac0513622c4ecf0bb70880 https://doi.org/10.1021/acs.orglett.9b01832 Zobrazit plný text záznamu