Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 1. Heteroarylamine derivatives

Autor:	Robert D. Reynolds, Cynthia Barcelon-Yang, Barry S. Brown, David M. Stout, William L. Matier
Rok vydání:	1983
Předmět:	Male Changrolin Guinea Pigs Substituent Parasympatholytics Parasympatholytic chemistry.chemical_compound Dogs chemistry Ileum Drug Discovery Quinazolines Molecular Medicine Organic chemistry Animals Phenols Anti-Arrhythmia Agents Muscle Contraction
Zdroj:	Journal of medicinal chemistry. 26(6)
ISSN:	0022-2623
Popis:	Twenty-four structural derivatives of the antiarrhythmic drug changrolin were synthesized and tested for antiarrhythmic and parasympatholytic activities. It was found that while the bis(pyrrolidinylmethyl)phenol pattern of changrolin appeared to be optimal in this series, a wide latitude existed for the heteroaryl substituent for maintaining good antiarrhythmic activity. Further, the antiarrhythmic and parasympatholytic activities tended to exhibit parallel changes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01e08536ad6f7105559c38cdf439389 https://pubmed.ncbi.nlm.nih.gov/6854583 Zobrazit plný text záznamu