Black and White Female Adolescents Lose Vitamin D Metabolites into Urine
| Autor: | Rafiq El Hammali, Cristina Palacios, Stacy Cephas, Connie M. Weaver, Myrtle Thierry-Palmer, Berdine R. Martin, Veronica M. Henderson |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty 24 25-Dihydroxyvitamin D 3 Adolescent Diet therapy Urinary system Metabolite Sodium White female chemistry.chemical_element Urine White People chemistry.chemical_compound Internal medicine medicine Vitamin D and neurology Humans Sodium Chloride Dietary Vitamin D Child business.industry General Medicine Black or African American Endocrinology chemistry Female business Negroid |
| Zdroj: | The American Journal of the Medical Sciences. 335:278-283 |
| ISSN: | 0002-9629 |
| Popis: | Background The black American population has a higher prevalence of salt sensitivity compared with the white American population. Dahl salt-sensitive rats, models of salt-induced hypertension, excrete protein-bound vitamin D metabolites into urine, a process that is accelerated during high salt intake. We tested the hypothesis that urinary vitamin D metabolite content and 25-hydroxyvitamin D (25-OHD) binding activity of black female adolescents would be greater than that of white female adolescents. Methods Female adolescents (11–15 years old, 11 black and 10 white) were fed low (1.3 g, 56 mmol/24 hours sodium) and high salt (3.86 g, 168 mmol/24 hours sodium) diets for 3 weeks in a randomized order cross-over study design. Results White and black adolescents had similar mean urinary vitamin D metabolite content (low salt, black versus white: 50 ± 10 versus 58 ± 17 pmol/24 hours; high salt, black versus white: 47 ± 7 versus 79 ± 16 pmol/24 hours). Mean urinary 25-OHD binding activities of the black and white adolescents did not significantly differ. Urinary 25-OHD binding activity of 10/11 black adolescents and 7/10 white adolescents was greater at week 3 of high salt intake than at week 3 of low salt intake (r = 0.50, P = 0.002, n = 17). Plasma 24,25-dihydroxyvitamin D concentrations of the white female adolescents were significantly higher than that of the black female adolescents ( P Conclusion Urinary loss of vitamin D metabolites may be one cause of low vitamin D status, in addition to low dietary intake and reduced skin synthesis. |
| Databáze: | OpenAIRE |
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