Anti-MOG autoantibody-associated schizophreniform psychosis
| Autor: | Harald Prüss, Katharina von Zedtwitz, Isabelle Matteit, Katharina Domschke, Horst Urbach, Maike Michel, Ludger Tebartz van Elst, Miriam A. Schiele, Bernd Feige, Dominik Denzel, Dominique Endres, Kathrin Nickel, Kimon Runge, Benjamin Berger, Andrea Schlump |
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| Rok vydání: | 2021 |
| Předmět: |
autoimmune psychosis
Psychosis Encephalomyelitis Context (language use) Immunoglobulin G Myelin oligodendrocyte glycoprotein medicine MOG Humans ddc:610 MOG encephalomyelitis Biological Psychiatry immunology [Myelin-Oligodendrocyte Glycoprotein] Autoantibodies Autoimmune encephalitis biology business.industry MOG protein human Autoantibody medicine.disease Magnetic Resonance Imaging Hyperintensity autoimmune encephalitis Psychiatry and Mental health Psychotic Disorders Immunology biology.protein Myelin-Oligodendrocyte Glycoprotein business |
| Zdroj: | Acta neuropsychiatrica 34(1), 47-54 (2022). doi:10.1017/neu.2021.29 |
| ISSN: | 1601-5215 0924-2708 |
| DOI: | 10.1017/neu.2021.29 |
| Popis: | Objectives:Autoimmune mechanisms are related to disease development in a subgroup of patients with psychosis. The contribution of immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) is mainly unclear in this context.Methods:Therefore, two patients with psychosis and anti-MOG antibodies – detected in fixed cell-based and live cell-based assays – are presented.Results:Patient 1 suffered from late-onset psychosis with singular white matter lesions in magnetic resonance imaging (MRI) and intermittent electroencephalography (EEG) slowing. Patient 2 suffered from a chronic paranoid–hallucinatory disorder with intermittent confusional states, non-specific white matter alterations on MRI, a disorganised alpha rhythm on EEG, and elevated cerebrospinal fluid protein. Both patients had anti-MOG antibody titres of 1 : 320 in serum (reference < 1 : 20).Conclusions:The arguments for and against a causal role for anti-MOG antibodies are discussed. The antibodies could be relevant, but due to moderate titres, they may have caused a rather ‘subtle clinical picture’ consisting of psychosis instead of ‘classical’ MOG encephalomyelitis. |
| Databáze: | OpenAIRE |
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