Divided genomes and intrinsic noise
Autor: | J. Pressing, D. C. Reanney |
---|---|
Jazyk: | angličtina |
Rok vydání: | 1984 |
Předmět: |
RNA viruses
Reassortment Copying fidelity Computational biology medicine.disease_cause Virus Replication Genome Article chemistry.chemical_compound Genetic variation Genetics medicine Selection Genetic Molecular Biology Ecology Evolution Behavior and Systematics Mutation Divided genomes Intrinsic selection pressure biology RNA Genetic Variation RNA virus biology.organism_classification Biological Evolution chemistry Viral replication RNA Viral DNA |
Zdroj: | Journal of Molecular Evolution |
ISSN: | 1432-1432 0022-2844 |
Popis: | Segmental genomes (i.e., genomes in which the genetic information is dispersed between two or more discrete molecules) are abundant in RNA viruses, but virtually absent in DNA viruses. It has been suggested that the division of information in RNA viruses expands the pool of variation available to natural selection by providing for the reassortment of modular RNAs from different genetic sources. This explanation is based on the apparent inability of related RNA molecules to undergo the kinds of physical recombination that generate variation among related DNA molecules. In this paper we propose a radically different hypothesis. Self-replicating RNA genomes have an error rate of about 10(-3) - 10(-4) substitutions per base per generation, whereas for DNA genomes the corresponding figure is 10(-9) - 10(-11). Thus the level of noise in the RNA copier process is five to eight orders of magnitude higher than that in the DNA process. Since a small module of information has a higher chance of passing undamaged through a noisy channel than does a large one, the division of RNA viral information among separate small units increases its overall chances of survival. The selective advantage of genome segmentation is most easily modelled for modular RNAs wrapped up in separate viral coats. If modular RNAs are brought together in a common viral coat, segmentation is advantageous only when interactions among the modular RNAs are selective enough to provide some degree of discrimination against miscopied sequences. This requirement is most clearly met by the reoviruses. |
Databáze: | OpenAIRE |
Externí odkaz: |