Experimental therapeutic assays of Tephrosia vogelii against Leishmania major infection in murine model: in vitro and in vivo
| Autor: | Christopher Khayeka-Wandabwa, Bernard Ngoitsi Jumba, Eric Onyango Adino, Christopher O. Anjili, Joseph K. Choge, Sylvia Naliaka Marango, Judith Makwali |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pentostam lcsh:Medicine Pharmacology Mice 0302 clinical medicine Amphotericin B Tephrosia vogelii Leishmania major 50% inhibitory concentration lcsh:QH301-705.5 Leishmaniasis Mice Inbred BALB C biology In vitro toxicology General Medicine Organ Size Research Note Liver Tephrosia medicine.drug Efficacy 030106 microbiology 030231 tropical medicine Leishmaniasis Cutaneous Context (language use) Nitric Oxide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Inhibitory Concentration 50 In vivo medicine Animals lcsh:Science (General) Amastigote IC50 Toxicity business.industry Plant Extracts lcsh:R Body Weight biology.organism_classification Disease Models Animal lcsh:Biology (General) Antimony Sodium Gluconate business Spleen lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 10, Iss 1, Pp 1-12 (2017) |
| ISSN: | 1756-0500 |
| Popis: | Background Conventional targeted leishmanicidal chemotherapy has persistently remained prohibitive for most economically deprived communities due to costs, associated time to accessing health services and duration for successful treatment programme. Alternatives are bound to be incorporated in rational management of leishmaniasis by choice or default due to accessibility and cultural beliefs. Therefore, there is need to rigorously investigate and appraise the activity of medicinal compounds that may have anti-leishmanicidal activity especially in the context of products that are already being utilized by the populations for other ailments but have limited information on their therapeutic value and possible cytoxicity. Hence, the study examined both in vivo and in vitro response of L. major infection to Tephrosia vogelii extracts in BALB/c mice as the mouse model. Methods A comparative study design was applied for the in vivo and in vitro assays of the extract with Pentostam (GlaxoSmithKline, UK) and Amphotericin B [Fungizone™, X-Gen Pharmaceuticals (US)] as standard drugs. Results In BALB/c mice where the chemotherapeutic extract was administered intraperitoneally, there was significantly (p |
| Databáze: | OpenAIRE |
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