Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes
| Autor: | Mohamed Teleb, Kyari Sumayin Ngamdu, Erica Borrego, Gehan Botrus, Gerardo Maldonado, Richard W. McCallum, Omar Baker, Ahmed M. Hussein, Jose L. Gonzales Martinez |
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| Rok vydání: | 2017 |
| Předmět: |
Joint hypermobility
Adult Joint Instability Male Gi symptoms medicine.medical_specialty Gastroparesis Benign joint hypermobility Adolescent Gastrointestinal Diseases Population 03 medical and health sciences Postural Orthostatic Tachycardia Syndrome Young Adult 0302 clinical medicine medicine Humans Prospective Studies Intestinal Mucosa education Hypermobility (travel) Aged Retrospective Studies 030203 arthritis & rheumatology education.field_of_study business.industry General Medicine Middle Aged medicine.disease Dermatology Review article Rectal Diseases Ehlers–Danlos syndrome Research Design Anxiety 030211 gastroenterology & hepatology Female medicine.symptom business |
| Zdroj: | The American journal of the medical sciences. 355(6) |
| ISSN: | 1538-2990 |
| Popis: | Joint hypermobility is a common, primarily benign finding in the general population. However, in a subset of individuals joint hypermobility causes a range of clinical problems mainly affecting the musculoskeletal system and, to a lesser extent, extra-articular disorders. Joint hypermobility often appears as a familial trait and is shared by several inherited connective tissue disorders, including the hypermobility subtype of Ehlers-Danlos syndrome (hEDS) and benign joint hypermobility syndrome (BJHS/JHS). Although joint hypermobility has primarily been thought of as a rheumatological disorder, increasing evidence shows significant associations between both hEDS and BJHS with specific extra-articular disorders. To date, the strongest associations of these 2 conditions are with anxiety disorders, orthostatic tachycardia, various functional gastrointestinal (GI) disorders and pelvic and bladder dysfunction. This review article focuses on GI disorders associated with both hEDS and BJHS. The aim of this review is to evaluate existing research and literature regarding associations between JHS (hEDS/BJHS) and GI disorders. Our goal is to raise awareness of BJHS/JHS and hEDS as an explanation for chronic unexplained symptoms and functional GI disorders as well as to review the current standard tests available for proper evaluation of GI symptoms in these patients. |
| Databáze: | OpenAIRE |
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