Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes
| Autor: | Aki Hiuge-Shimizu, Ken Kishida, Hideaki Nakatsuji, Ayumu Hirata, Iichiro Shimomura, Tohru Funahashi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Arteriosclerosis Coronary Artery Disease Type 2 diabetes Coronary Angiography Iliac Artery Risk Assessment Coronary artery disease Electrocardiography Renal Artery Japan Predictive Value of Tests Risk Factors medicine.artery medicine Humans Aorta Abdominal Ultrasonography Interventional Aged Aged 80 and over Chi-Square Distribution business.industry Abdominal aorta Myocardial Perfusion Imaging Area under the curve Type 2 Diabetes Mellitus Middle Aged Prognosis medicine.disease Carotid Arteries Cross-Sectional Studies Early Diagnosis Logistic Models Diabetes Mellitus Type 2 Intima-media thickness Female Radiology Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Body mass index Diabetic Angiopathies |
| Zdroj: | Atherosclerosis. 219:623-629 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2011.08.043 |
| Popis: | Patients with type 2 diabetes mellitus (T2DM) are at risk of polyvascular comorbidities and poor prognosis. Non-invasive techniques for early prediction of coronary artery disease (CAD) are desirable to prevent cardiovascular events in these patients. The aim of the present study was to investigate the association between CAD and systemic arteriosclerosis by qualitative vascular ultrasonography.The study subjects were 102 consecutive outpatients with T2DM [males/females = 60/42, age: mean ± SD 67 ± 9 (range, 40-85) years] evaluated by vascular ultrasonography for arteriosclerosis in the abdominal aorta, carotid, renal, and common iliac arteries. The total number of detected arteriosclerotic vascular lesions in the four arteries was determined. CAD was diagnosed by two cardiologists using either stress electrocardiography, myocardial scintigraphy, multi-detector row computed tomography or coronary angiography.Multiple arteriosclerotic vascular lesions (1) were detected in 64 (63%) patients. The total systemic vascular score was significantly higher in patients with CAD than those without (average score 2.7 versus 1.0, p0.0001). None of the CAD patients had a total score of 0. Age- and sex-adjusted multiple logistic regression analysis identified total score of ≥ 2 as the only predictor of CAD (p0.001). The sensitivity, specificity, positive and negative predictive values for total systemic vascular score in the prediction of CAD were 98%, 77%, 83%, and 97%, respectively, which were better than those for carotid mean and maximum intima-media thickness.Non-invasive qualitative evaluation of systemic arteriosclerosis by the total systemic vascular score is potentially useful for the early prediction of CAD in T2DM patients. |
| Databáze: | OpenAIRE |
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