Longitudinal changes in microstructural white matter metrics in Alzheimer's disease
| Autor: | Jodie R. Gawryluk, Erin L. Mazerolle, Chantel D Mayo, John D. Fisk, Lesley Ritchie |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Aging MMSE Mini Mental Status Exam Databases Factual ROI region of interest Corpus callosum lcsh:RC346-429 FSL Functional MRI of the Brain Software Library 0302 clinical medicine Cingulum (brain) Longitudinal Studies FA fractional anisotropy HC healthy controls Aged 80 and over TBSS Tract-Based Spatial Statistics White matter Regular Article Alzheimer's disease Diffusion Tensor Imaging medicine.anatomical_structure Neurology MCI mild cognitive impairment Disease Progression lcsh:R858-859.7 Female AD Alzheimer's disease Psychology Cognitive Neuroscience Uncinate fasciculus Grey matter lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences Magnetic resonance imaging Alzheimer Disease Fractional anisotropy medicine Humans Radiology Nuclear Medicine and imaging Inferior longitudinal fasciculus lcsh:Neurology. Diseases of the nervous system Aged MD mean diffusivity ADNI Alzheimer's Disease Neuroimaging Initiative 030104 developmental biology WMS Wechsler Memory Scale DTI diffusion tensor imaging Neurology (clinical) MRI magnetic resonance imaging Neuroscience Biomarkers 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 13, Iss C, Pp 330-338 (2017) |
| ISSN: | 2213-1582 |
| Popis: | Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current avenues of AD research focus on pre-symptomatic biomarkers that will assist with early diagnosis of AD. The majority of magnetic resonance imaging (MRI) based biomarker research to date has focused on neuronal loss in grey matter and there is a paucity of research on white matter. Methods Longitudinal DTI data from the Alzheimer's Disease Neuroimaging Initiative 2 database were used to examine 1) the within-group microstructural white matter changes in individuals with AD and healthy controls at baseline and year one; and 2) the between-group microstructural differences in individuals with AD and healthy controls at both time points. Results 1) Within-group: longitudinal Tract-Based Spatial Statistics revealed that individuals with AD and healthy controls both had widespread reduced fractional anisotropy (FA) and increased mean diffusivity (MD) with changes in the hippocampal cingulum exclusive to the AD group. 2) Between-group: relative to healthy controls, individuals with AD had lower FA and higher MD in the hippocampal cingulum, as well as the corpus callosum, internal and external capsule; corona radiata; posterior thalamic radiation; superior and inferior longitudinal fasciculus; fronto-occipital fasciculus; cingulate gyri; fornix; uncinate fasciculus; and tapetum. Conclusion The current results indicate that sensitivity to white matter microstructure is a promising avenue for AD biomarker research. Additional longitudinal studies on both white and grey matter are warranted to further evaluate potential clinical utility. Highlights • Longitudinal white matter research in Alzheimer's disease. • Diffusion tensor imaging used to assess microstructural white matter changes. • Decreased fractional anisotropy and increased mean diffusivity over one year. • Widespread changes in Alzheimer's disease include the hippocampal cingulum. • DTI holds potential as Alzheimer's disease biomarker. |
| Databáze: | OpenAIRE |
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