Effect of Demineralized Bone Matrix on Bone Growth within a Porous HA Material: A Histologic and Histometric Study
| Autor: | Christopher J. Damien, Annamarie B. Preweit, J. Russell Parsons, Ralph E. Holmes, Edwin C. Shors, Frank Huismans |
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| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
Ceramics Materials science Surface Properties education Composite number Biomedical Engineering Bone Matrix Dentistry Biomaterials Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Osseointegration Materials Testing parasitic diseases medicine Animals Bone growth Bone Demineralization Technique Demineralized bone matrix business.industry Skull dBm Biomaterial Prostheses and Implants 030206 dentistry Demineralization Microscopy Electron Durapatite 030104 developmental biology Calcium carbonate medicine.anatomical_structure chemistry Bone Substitutes Rabbits business Cancellous bone Biomedical engineering |
| Zdroj: | Journal of Biomaterials Applications. 9:275-288 |
| ISSN: | 1530-8022 0885-3282 |
| DOI: | 10.1177/088532829500900306 |
| Popis: | Coralline hydroxyapatite (cHA) is an osteoconductive material currently being used as a bone graft substitute. Created by the hydrothermal conversion of the calcium carbonate skeleton of coral to hydroxyapatite, this material has a porous structure similar to cancellous bone. Addition of demineralized bone matrix (DBM) would conceivably create a composite with both osteoconductive and osteoinductive properties. This pilot study evaluated the healing of rabbit cranial defects that had been filled with cHA or cHA augmented with a DBM gel formed by adding glycerol to the DBM particulate. Data from these were then compared to unfilled defects from a previous study. Results indicated enhancement of new bone formation and an increase in the rate of healing in the defects filled with the cHA-DBM gel composite. Further studies are warranted. |
| Databáze: | OpenAIRE |
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