The epidemiology of Plasmodium falciparum and Plasmodium vivax in East Sepik Province, Papua New Guinea, pre- and post-implementation of national malaria control efforts
| Autor: | Benson Kiniboro, Johanna Helena Kattenberg, Naomi Sambale, Matthew Philip, Maria Ome-Kaius, James W. Kazura, Ivo Mueller, Shadrach Jally, Peter Siba, Dulcie L Gumal, Stephan Karl, Leanne J. Robinson, Bernadine Kasian, Alyssa E. Barry, Ingrid Felger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cross-sectional study Epidemiology LLINs Plasmodium vivax law.invention law Prevalence Medicine Malaria Falciparum Child biology Middle Aged Infectious Diseases Transmission (mechanics) Child Preschool Spatial heterogeneity Female Adult medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Malaria control Plasmodium falciparum lcsh:Infectious and parasitic diseases Papua New Guinea Young Adult Environmental health parasitic diseases Malaria Vivax Humans lcsh:RC109-216 Aged business.industry Public health Research Infant Newborn Infant biology.organism_classification medicine.disease Malaria Child mortality Cross-Sectional Studies Communicable Disease Control Parasitology business |
| Zdroj: | Malaria Journal Malaria Journal, Vol 19, Iss 1, Pp 1-18 (2020) |
| ISSN: | 1475-2875 |
| Popis: | Background In the past decade, national malaria control efforts in Papua New Guinea (PNG) have received renewed support, facilitating nationwide distribution of free long-lasting insecticidal nets (LLINs), as well as improvements in access to parasite-confirmed diagnosis and effective artemisinin-combination therapy in 2011–2012. Methods To study the effects of these intensified control efforts on the epidemiology and transmission of Plasmodium falciparum and Plasmodium vivax infections and investigate risk factors at the individual and household level, two cross-sectional surveys were conducted in the East Sepik Province of PNG; one in 2005, before the scale-up of national campaigns and one in late 2012-early 2013, after 2 rounds of LLIN distribution (2008 and 2011–2012). Differences between studies were investigated using Chi square (χ2), Fischer’s exact tests and Student’s t-test. Multivariable logistic regression models were built to investigate factors associated with infection at the individual and household level. Results The prevalence of P. falciparum and P. vivax in surveyed communities decreased from 55% (2005) to 9% (2013) and 36% to 6%, respectively. The mean multiplicity of infection (MOI) decreased from 1.8 to 1.6 for P. falciparum (p = 0.08) and from 2.2 to 1.4 for P. vivax (p 50% of household members with Plasmodium infection). Conclusion After the scale-up of malaria control interventions in PNG between 2008 and 2012, there was a substantial reduction in P. falciparum and P. vivax infection rates in the studies villages in East Sepik Province. Understanding the extent of local heterogeneity in malaria transmission and the driving factors is critical to identify and implement targeted control strategies to ensure the ongoing success of malaria control in PNG and inform the development of tools required to achieve elimination. In household-based interventions, diagnostics with a sensitivity similar to (expert) microscopy could be used to identify and target high rate households. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink