High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer
| Autor: | Fei Meng, Wen-Li Zhan, Zhou-Tong Dai, Yun-Qian Cui, Xinghua Liao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Transcriptional Activation
China Article Subject Gene Expression Kidney General Biochemistry Genetics and Molecular Biology Downregulation and upregulation Cell Line Tumor Databases Genetic Biomarkers Tumor Humans Medicine Carcinoma Renal Cell Cell Proliferation Renal clear cell carcinoma General Immunology and Microbiology business.industry Cell growth Gene Expression Profiling Cancer General Medicine medicine.disease Kidney Neoplasms In vitro DNA-Binding Proteins Gene Expression Regulation Neoplastic medicine.anatomical_structure Cell culture Cancer research Transcriptome business Clear cell Research Article Signal Transduction |
| Zdroj: | BioMed Research International, Vol 2021 (2021) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2021/5282894 |
| Popis: | This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment. |
| Databáze: | OpenAIRE |
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