Novel, Potentially Zoonotic Paramyxoviruses from the African Straw-Colored Fruit Bat Eidolon helvum
| Autor: | Benjamin K. Amos, James L. N. Wood, Shawn Todd, Hugh Reyburn, Alexandra O. Kamins, Glenn A. Marsh, David T. S. Hayman, Andrew A. Cunningham, Kate S. Baker, Gary Crameri, Jennifer A. Barr, Lin-Fa Wang, Edward Nyarko, Meng Yu, George Mtove, Alison J. Peel, Behzad Nadjm, Pablo R. Murcia, Richard Suu-Ire |
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| Rok vydání: | 2013 |
| Předmět: |
education.field_of_study
viruses Immunology Population Biology biology.organism_classification Microbiology Plasmodium people.cause_of_death Virology Virus Eidolon helvum Genetic Diversity and Evolution Tioman virus Insect Science parasitic diseases Veterinary virology Menangle virus education people Horizontal transmission |
| Zdroj: | Journal of Virology. 87:1348-1358 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Bats carry a variety of paramyxoviruses that impact human and domestic animal health when spillover occurs. Recent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw-colored fruit bats in Ghana. Here, we investigate this further through virus isolation and describe two novel rubulaviruses: Achimota virus 1 (AchPV1) and Achimota virus 2 (AchPV2). The viruses form a phylogenetic cluster with each other and other bat-derived rubulaviruses, such as Tuhoko viruses, Menangle virus, and Tioman virus. We developed AchPV1- and AchPV2-specific serological assays and found evidence of infection with both viruses in Eidolon helvum across sub-Saharan Africa and on islands in the Gulf of Guinea. Longitudinal sampling of E. helvum indicates virus persistence within fruit bat populations and suggests spread of AchPVs via horizontal transmission. We also detected possible serological evidence of human infection with AchPV2 in Ghana and Tanzania. It is likely that clinically significant zoonotic spillover of chiropteran paramyxoviruses could be missed throughout much of Africa where health surveillance and diagnostics are poor and comorbidities, such as infection with HIV or Plasmodium sp., are common. |
| Databáze: | OpenAIRE |
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