Phloretin ameliorates diabetic nephropathy by inhibiting nephrin and podocin reduction through a non-hypoglycemic effect

Autor:	Jia Liu, Mingcheng Sun, Yong Xia, Xiaopei Cui, Jingjing Jiang
Rok vydání:	2022
Předmět:	Mice Diabetes Mellitus Type 2 Phloretin Podocytes Intracellular Signaling Peptides and Proteins Animals Membrane Proteins Diabetic Nephropathies General Medicine Food Science Diabetes Mellitus Experimental
Zdroj:	Foodfunction. 13(12)
ISSN:	2042-650X
Popis:	Phloretin is a dihydrochalcone flavonoid from natural plants, which has protective activities against oxidative stress and inflammation. To date, its effect on diabetic nephropathy (DN) has not been investigated. In this study, we examined the potential role of phloretin in diabetes-induced renal damage and associated mechanisms in a type 2 diabetes mellitus (T2DM) model induced by streptozotocin (STZ) and high-fat diet (HFD) in Apolipoprotein E knockout (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00edb7c98f5247a89865fe8ad211319 https://pubmed.ncbi.nlm.nih.gov/35622066 Zobrazit plný text záznamu