Phloretin ameliorates diabetic nephropathy by inhibiting nephrin and podocin reduction through a non-hypoglycemic effect
Autor: | Jia Liu, Mingcheng Sun, Yong Xia, Xiaopei Cui, Jingjing Jiang |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Foodfunction. 13(12) |
ISSN: | 2042-650X |
Popis: | Phloretin is a dihydrochalcone flavonoid from natural plants, which has protective activities against oxidative stress and inflammation. To date, its effect on diabetic nephropathy (DN) has not been investigated. In this study, we examined the potential role of phloretin in diabetes-induced renal damage and associated mechanisms in a type 2 diabetes mellitus (T2DM) model induced by streptozotocin (STZ) and high-fat diet (HFD) in Apolipoprotein E knockout ( |
Databáze: | OpenAIRE |
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