Lactoferrin and oral pathologies: a therapeutic treatment
| Autor: | Luigi Rosa, Antimo Cutone, Livia Ottolenghi, Giusi Ianiro, Maria Stefania Lepanto, Stefania Pernarella, Piera Valenti, Riccardo Sangermano, Giovanni Musci |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Saliva Therapeutic treatment Administration Topical Inflammation Oral cavity Biochemistry 03 medical and health sciences Gingivitis 0302 clinical medicine medicine Animals Humans Molecular Biology Periodontitis Mouth biology Bacteria business.industry Lactoferrin therapeutic treatment 030206 dentistry Cell Biology medicine.disease Anti-Bacterial Agents stomatognathic diseases 030104 developmental biology Biofilms Immunology biology.protein medicine.symptom oral pathology business lactoferrin Anaerobic exercise |
| Zdroj: | Biochemistry and cell biology = Biochimie et biologie cellulaire. 99(1) |
| ISSN: | 1208-6002 |
| Popis: | The oral cavity is a non-uniform, extraordinary environment characterized by mucosal, epithelial, abiotic surfaces and secretions as saliva. Aerobic and anaerobic commensal and pathogenic microorganisms colonize the tongue, teeth, jowl, gingiva, and periodontium. Commensals exert an important role in host defenses, while pathogenic microorganisms can nullify this protective function causing oral and systemic diseases. Every day, 750–1000 mL of saliva, containing several host defense constituents including lactoferrin (Lf), are secreted and swallowed. Lf is a multifunctional iron-chelating cationic glycoprotein of innate immunity. Depending on, or regardless of its iron-binding ability, Lf exerts bacteriostatic, bactericidal, antibiofilm, antioxidant, antiadhesive, anti-invasive, and anti-inflammatory activities. Here, we report the protective role of Lf in different oral pathologies, such as xerostomia, halitosis, alveolar or maxillary bone damage, gingivitis, periodontitis, and black stain. Unlike antibiotic therapy, which is ineffective against bacteria that are within a biofilm, adherent, or intracellular, the topical administration of Lf, through its simultaneous activity against microbial replication, biofilms, adhesion, and invasiveness, as well as inflammation, has been proven to be efficient in the treatment of all known oral pathologies without any adverse effects. |
| Databáze: | OpenAIRE |
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