Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease
| Autor: | Yu-Hsien Lai, Jen-Pi Tsai, Sheng-Chao Wang, Chin-Hung Liu, Chih-Hsien Wang, Bang-Gee Hsu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty 030232 urology & nephrology Urology Comorbidity 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Kidney Function Tests 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Risk Factors Medicine Humans In patient Renal Insufficiency Chronic indoxyl sulfate Pulse wave velocity Aged Aged 80 and over business.industry General Medicine Middle Aged medicine.disease Arterial stiffness Diseases of the genitourinary system. Urology Cross-Sectional Studies Logistic Models Nephrology Carotid-Femoral Pulse Wave Velocity Multivariate Analysis Uremic toxins Clinical Study Indoxyl Sulfate Female RC870-923 Disease Susceptibility business Indican Biomarkers chronic kidney disease Kidney disease Research Article |
| Zdroj: | Renal Failure article-version (VoR) Version of Record Renal Failure, Vol 43, Iss 1, Pp 796-802 (2021) |
| ISSN: | 1525-6049 |
| Popis: | Background The role of indoxyl sulfate (IS), an important protein-bound uremic toxin, in arterial stiffness (AS) in patients with chronic kidney disease (CKD) is unclear. Materials and methods We investigated the association between serum IS levels and AS in a cross-sectional study of 155 patients with CKD. Patients in the AS group was defined as carotid-femoral pulse wave velocity (cfPWV) value >10 m/s measured by a validated tonometry system (SphygmoCor), while values ≤10 m/s were regarded as without AS group Serum IS was measured by liquid chromatography–mass spectrometry analysis. Results Of these CKD patients, AS was present in 51 (32.9%) patients, who were older, had a higher rate of diabetes, higher systolic blood pressure (SBP), and higher IS levels compared to those without AS. By multivariable logistic regression analysis, IS (adjusted odds ratio [aOR] 1.436, 95% confidence interval [CI] 1.085–1.901, p = 0.011), age (aOR 1.058, 95% CI 1.021–1.097, p = 0.002), and SBP (aOR 1.019, 95%CI 1.000–1.038, p = 0.049) were independent predictors of AS. By multivariable stepwise linear regression analysis, logarithmically transformed IS, age, DM, and SBP were significantly correlated with cfPWV. The area under the receiver-operating characteristic curve for serum log-IS was 0.677 (95%CI 0.598–0.750, p = 0.0001) to predict the development of AS in patients with CKD. Conclusion These finding demonstrate that in addition to older and higher SBP, a high serum IS level is a significant biomarker associated with AS in patients with CKD. |
| Databáze: | OpenAIRE |
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