Association of decrease in insula fMRI activation with changes in trait anxiety in patients with craniomandibular disorder (CMD)
| Autor: | K. Klepzig, E. Schenkenberger, Bernd Kordass, Martin Lotze, J. Dammann |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Anxiety behavioral disciplines and activities Young Adult 03 medical and health sciences Behavioral Neuroscience Craniomandibular Disorders 0302 clinical medicine Musculoskeletal Pain Outcome Assessment Health Care medicine Humans Longitudinal Studies 030304 developmental biology Cerebral Cortex Brain Mapping 0303 health sciences DASS business.industry Chronic pain Temporomandibular Joint Disorders Anticipation Psychological medicine.disease Magnetic Resonance Imaging Anticipation Functional imaging Splints Craniomandibular Disorder Physical therapy Chronic Pain medicine.symptom business Insula 030217 neurology & neurosurgery Personality Psychopathology |
| Zdroj: | Behavioural Brain Research. 379:112327 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2019.112327 |
| Popis: | Patients with chronic pain and especially with craniomandibular disorder (CMD) show specific psychopathology in trait anxiety. In a previous longitudinal functional imaging study on CMD we found that the anterior insula was modulated by successful therapy intervention and pain relief. We here intended to investigate possible associations between anterior insula fMRI-activation during occlusal movements and trait anxiety over a splint therapy approach in patients with CMD. Three fMRI-investigations of a craniomandibular occlusion task were performed together with pain score evaluations and scoring of trait anxiety (State –Trait Anxiety Inventory; STAI) before, after two weeks and after three months of a DIR-mandibular splint therapy in a small group (n = 9) of CMD patients. Patients showed increased anxiety levels before therapy assessed with the STAI and the depression and anxiety scale (DASS). Besides of relevant reduction in pain the STAI decreased over time. Reduction in STAI was associated with anterior insular fMRI-activation reduction on both hemispheres. We conclude that the anxiety driven anticipation of pain related to occlusal trigger is processed in the anterior insula and might therefore be a main driver of therapeutic intervention by the splint therapy in CMD. |
| Databáze: | OpenAIRE |
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